2022 Nobel Prize in Chemistry announced: Efficiently creating new chemical compound reactions.

Click chemistry” and “Bioorthogonal chemistry” techniques are now being used worldwide to explore the tracking of cellular and biological reaction processes.

By using bioorthogonal reactions, researchers have improved the targeting of cancer drugs, which are now being tested in clinical trials.

On October 5, the 2022 Nobel Prize in Chemistry was announced. Professor Barry Sharpless from the Scripps Institute in the United States, Morten Meldal from the University of Copenhagen in Denmark, and Carolyn Bertozzi from Stanford University in the United States shared the Nobel Prize in Chemistry.

 

Among them, Prof. Sharpless and Prof. Meldal won the award for their research on “click chemistry”, and Prof. Bertozzi won the award for pioneering the field of “bioorthogonal chemistry”.

In a nutshell, three scientists have discovered a way to bring molecular building blocks together to efficiently create new chemical reactions.

 

The Nobel Committee said in a statement that “click chemistry” and “bioorthogonal chemistry” techniques are now being used worldwide to explore the tracking of cellular and biological reaction processes.

By using bioorthogonal reactions, researchers have improved the targeting of cancer drugs, which are currently being tested in clinical trials,” the Nobel Committee said in the release.

 

It is worth mentioning that Professor Sharpless won the Nobel Prize in Chemistry in 2001 for his chiral catalytic oxidation reaction, and this is the second time he has won the Nobel Prize in Chemistry.

Professor Frederick Sanger has won the Nobel Prize in Chemistry twice in history, and he won twice in 1958 and 1980; in the field of physics, John Bardeen won twice; Marie Curie Won the Physics Prize and Chemistry Prize respectively.

 

 

 

Professor Michael Levitt, the winner of the 2013 Nobel Prize in Chemistry, told Yicai.com: “I am very happy that Sharpless has won the award again. He is an old friend of China and used to come often; Bertozzi won the award. I’m relieved that we’re all from Stanford.”

 

Professor Sharpless was an adjunct professor at the Shanghai Institute of Organic Chemistry. Before the epidemic, he often came to China to give lectures.

 

It is also worth mentioning that Bertozzi is the eighth woman to win the Nobel Prize in Chemistry.

“When I found out that I had won the award, I was completely stunned, sitting there and barely breathing,” she said in an interview late at night in California.

 

In recent years, the Nobel Prize in Chemistry has been awarded to less popular fields, and last year it was awarded to the inventor of “asymmetric organocatalysis”. For this year’s award-winning field, Ma Dawei expressed “somewhat surprised”.

 

“Click chemistry” is simply a rapid reaction that can quickly link two fragments together; bioorthogonal chemistry is to detect protein function in the process of life.

This time The two fields awarded by the Nobel Prize are related, and their purposes and application scenarios are the same, one is the chemical asymmetric synthesis of functional molecules, and the other is for the detection of protein functions in living systems.

 

Sharpless’s team wrote in a 2001 paper: “Nucleic acids, proteins, and polysaccharides are all spliced ​​together by carbon-heteroatom bonds from small molecules, the total number of which is only 35. If humans can learn this set of principles, they can quickly and reliably synthesize a large number of useful molecules.”

 

After the publication of the above paper, the field of “click chemistry” was born, which emphasizes the combination of molecules by carbon-heteroatom bonding.

At the same time, the reaction needs to have the characteristics of high yield, wide applicability, and harmless by-products. , advocates “simple and useful chemistry”.

At present, the “click chemistry” reaction has been widely used in many fields such as drug research and development, functional materials, supramolecular self-assembly, and chemical biology.

 

Bertozzi answered questions from reporters on the phone.

When talking about the application prospects of bioorthogonal chemistry, she said: “There are two main types of applications, one is the discovery of new biomolecules, and the other is in medicine, especially in drug delivery, where drugs can be delivered to the correct place.”

 

Bertozzi said that these emerging technologies are still in their infancy, and the field of bioorthogonal chemistry contributes to the development of biotechnology, especially in the diagnosis and treatment of diseases, which has great application prospects; and “click chemistry” is simple to operate and can already be For large-scale pharmaceutical applications, these emerging technologies will also show potential in the field of cancer immunotherapy in the future.

 

2022 Nobel Prize in Chemistry announced: Efficiently creating new chemical compound reactions